S. Palanduz et al., IN-VITRO CHROMOSOMAL RADIOSENSITIVITY IN COMMON VARIABLE IMMUNE-DEFICIENCY, Clinical immunology and immunopathology, 86(2), 1998, pp. 180-182
Common variable immune deficiency (CVID) is characterized by low immun
oglobulin levels and recurrent infections in patients with a period of
normal immune function several gears after birth, It is associated wi
th diarrhea, malabsorption, bronchiectasis, and lymphoreticular malign
ancies, Radiation-induced chromosome instability mag contribute to the
high degree of susceptibility to neoplasia. Peripheral blood lymphocy
te cultures were obtained from six patients with CVID and the healthy
control group matched by age and sex, The groups did not differ in the
frequency of spontaneous chromosome aberrations. After exposure to X-
ray radiation, mitotic indices were found to be significantly low and
incidence of chromosomal alterations were high in the CVID group. We c
onclude that chromosomes: of cells from patients with CVID are signifi
cantly more. radiosensitive than those of controls, Thus these patient
s must be protected from unnecessary X-ray examinations and in case of
radiosensitive tumour, the dose of irradiation should be carefully mo
nitored. (C) 1998 Academic Press.