PRODUCTION OF A RAS FARNESYL-PROTEIN TRANSFERASE INHIBITOR FROM BACILLUS-LICHENIFORMIS USING PLACKETT-BURMAN DESIGN

Authors
SON KH HONG SH KWON YK BAE KS KIM YK KWON BM KIM SU BOK SH
Citation
Kh. Son et al., PRODUCTION OF A RAS FARNESYL-PROTEIN TRANSFERASE INHIBITOR FROM BACILLUS-LICHENIFORMIS USING PLACKETT-BURMAN DESIGN, Biotechnology letters, 20(2), 1998, pp. 149-151
Citations number
12
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Biotechnology letters → ACNP
ISSN journal
01415492
Volume
20
Issue
2
Year of publication
1998
Pages
149 - 151
Database
ISI
SICI code
0141-5492(1998)20:2<149:POARFT>2.0.ZU;2-X
Abstract
Compound CBR004 which inhibits Ras farnesyl protein transferase, was p roduced by Bacillus licheniformis KCTC0372BP. Potassium phosphate and Tryptone were selected as media components for the production of CBR00 4 among 6 culture-variables using Plackett-Burman design. The yield of CBR004 was 0.99 g/l in a stirred fermenter at the C/N ratio of 1.87.