CHIRAL SYNTHESIS OF ALPHA-PHENYLPYRIDYLMETHANOLS WITH RHIZOPUS-ARRHIZUS

Authors
SALVI NA UDUPA SR BANERJI A
Citation
Na. Salvi et al., CHIRAL SYNTHESIS OF ALPHA-PHENYLPYRIDYLMETHANOLS WITH RHIZOPUS-ARRHIZUS, Biotechnology letters, 20(2), 1998, pp. 201-203
Citations number
8
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Biotechnology letters → ACNP
ISSN journal
01415492
Volume
20
Issue
2
Year of publication
1998
Pages
201 - 203
Database
ISI
SICI code
0141-5492(1998)20:2<201:CSOAWR>2.0.ZU;2-5
Abstract
The bioreduction of 2-benzoylpyridine (1a) with Rhizopus arrhizus affo rded (S)-(+)-alpha-phenyl-2-pyridylmethanol (2a) in 82% enantiomeric e xcess (e. e.) while the asymmetric hydrolysis of its racemic acetate r esulted in the antipode (R)-(-)-2a with 24% optical purity.