THE MECHANISM OF COUPLING OF THE ORGANIC ANION-EXCHANGE TO NA+ DICARBOXYLATE SYMPORT IN BASOLATERAL MEMBRANE-VESICLES/

Authors
REBANE EN ORLOV YN KAZBEKOV EN LJUBIMOV Y BULAT MN
Citation
En. Rebane et al., THE MECHANISM OF COUPLING OF THE ORGANIC ANION-EXCHANGE TO NA+ DICARBOXYLATE SYMPORT IN BASOLATERAL MEMBRANE-VESICLES/, Biologiceskie membrany, 15(1), 1998, pp. 43-47
Citations number
18
Categorie Soggetti
Cell Biology
Journal title
Biologiceskie membrany → ACNP
ISSN journal
02334755
Volume
15
Issue
1
Year of publication
1998
Pages
43 - 47
Database
ISI
SICI code
0233-4755(1998)15:1<43:TMOCOT>2.0.ZU;2-R
Abstract
The mechanism of energetic coupling of the organic anion transport to the gradient of Na+ has Seen investigated in basolateral membrane vesi cles from the rat kidney cortex. The uphill transport of p-aminohippur ic and uric acids was shown to occur upon the coupling of Na+/alpha-ke toglutarate symport and organic anion/alpha-ketoglutarate exchange. Ba sed on the of differences in the dynamics of p-aminohippurate and uric acid uptake by the vesicles, it was proposed that anion exchange is a limiting step of the coupling mechanism.