SOLID-STATE CHARACTERIZATION AND DISSOLUTION CHARACTERISTICS OF GLICLAZIDE-BETA-CYCLODEXTRIN INCLUSION COMPLEXES

Authors
MOYANO JR ARIASBLANCO MJ GINES JM GIORDANO F
Citation
Jr. Moyano et al., SOLID-STATE CHARACTERIZATION AND DISSOLUTION CHARACTERISTICS OF GLICLAZIDE-BETA-CYCLODEXTRIN INCLUSION COMPLEXES, International journal of pharmaceutics, 148(2), 1997, pp. 211-217
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
148
Issue
2
Year of publication
1997
Pages
211 - 217
Database
ISI
SICI code
0378-5173(1997)148:2<211:SCADCO>2.0.ZU;2-Z
Abstract
Solid complexes between gliclazide and beta-cyclodextrin (beta-CD) wer e prepared by kneading, coprecipitation, neutralization, co-grinding a nd spray-drying. Characterization of glicrazide-beta-CD inclusion comp lexes was performed using X-ray diffractometry and cross polarizing/ma gic angle spinning C-13-nuclear magnetic resonance spectroscopy. These techniques have clearly demonstrated the existence of solid-state inc lusion compound formation. The complexes, obtained by neutralization a nd spray-drying methods, showed enhanced dissolution rates of gliclazi de. (C) 1997 Elsevier Science B.V.