INJECTING SKIN FIBROBLASTS INTO MUSCLES TO EXPRESS HUMAN CLOTTING FACTOR-IX CDNA

Authors
WANG HW YANG XQ XING YN LU DR QIU XF XUE JL
Citation
Hw. Wang et al., INJECTING SKIN FIBROBLASTS INTO MUSCLES TO EXPRESS HUMAN CLOTTING FACTOR-IX CDNA, SCIENCE IN CHINA SERIES C-LIFE SCIENCES, 41(2), 1998, pp. 146-150
Citations number
9
Categorie Soggetti
Biology
Journal title
SCIENCE IN CHINA SERIES C-LIFE SCIENCES → ACNP
ISSN journal
10069305
Volume
41
Issue
2
Year of publication
1998
Pages
146 - 150
Database
ISI
SICI code
1006-9305(1998)41:2<146:ISFIMT>2.0.ZU;2-6
Abstract
Primary rabbit skin fibroblasts (RSF) containing lacZ reporter gene or human clotting factor IX (hFIX) cDNA could long-termly exist and be e xpressed after being implanted in rabbit muscles. Among them, the beta -glactosidase expression lasted at least 3 months, and hFIX expression lasted 1 month. These results will he helpful to organically combine the advantages of both skin fibroblasts and muscle, and provide a new way for somatic gene therapy of hemophilia B and other genetic disease s.