This paper provides empirical evidence on the leading factors affectin
g the prices of new pharmaceuticals, bath at introduction and after 4,
6, and 8 years. Most important is the extent of therapeutic advance e
mbodied in a new product, For drugs which represent important therapeu
tic gains, launch prices can be two or three times those of existing d
rugs used for the same purposes, while drugs that largely duplicate th
e actions of currently available products are typically priced al comp
arable levels. In addition, the number of branded substitutes has a su
bstantial negative effect on launch prices, which reflects the importa
nce of competitive pressures. Duplicate products thereby play an impor
tant economic role in pharmaceutical markets.