POEMS syndrome is a multisystemic disorder related to a plasma cell dy
scrasia. Radiologically, this syndrome is characterized by sclerotic f
ocal bone lesions with a normal radionuclide bone scan. We report a ca
se of POEMS syndrome with an expansile lytic lesion in the sternum sho
wing periosteal reaction and soft tissue mass, which revealed locally
increased uptake of radiotracer in bone scintigraphy. These unusual fi
ndings and the differential diagnosis are discussed.