COMPARISON OF STRUCTURAL-PROPERTIES OF HOMOLOGOUS PROTEINS HUMAN SERUM-ALBUMIN AND ALPHA-FETOPROTEIN

Authors
NARIZHNEVA NV IVANOVA TV TOMASHEVSKII AY UVERSKII VN
Citation
Nv. Narizhneva et al., COMPARISON OF STRUCTURAL-PROPERTIES OF HOMOLOGOUS PROTEINS HUMAN SERUM-ALBUMIN AND ALPHA-FETOPROTEIN, Molecular biology, 31(6), 1997, pp. 891-896
Citations number
14
Categorie Soggetti
Biology
Journal title
Molecular biology → ACNP
ISSN journal
00268933
Volume
31
Issue
6
Year of publication
1997
Pages
891 - 896
Database
ISI
SICI code
0026-8933(1997)31:6<891:COSOHP>2.0.ZU;2-L
Abstract
Structural properties of homologous proteins human serum albumin (SA) and human a-fetoprotein (AFP) were studied by circular dichroism, fluo rescence spectroscopy, and scanning microcalorimetry. The influence of natural hydrophobic ligands on the stability of these proteins was st udied. Removal of the ligands from AFP was shown to transfer it irreve rsibly into a molten globule state. However, such treatment only desta bilized SA but did not lead to a conformational transition.