Introduction: Endoscopic erbium-YAG laser treatment is a new approach
in glaucoma surgery. In contrast to conventional laser systems, the ph
otoablative erbium-YAG laser allows microperforations of the trabecula
r meshwork without thermal side effects. We report our first preclinic
al trials using this new system.Method: We used the Endognost system (
Schwind Co.). The device combines an endoscope and illumination fiber
(0.5 mm diameter), laser fiber (0.5 mm) and a irrigation tube in one p
robe with a 1.1 mm external diameter. The Endognost system was tested
in porcine and enucleated human eyes. All eyes were examined histologi
cally. Results: The endoscopic view into the anterior chamber allows f
or precise allocation of the laser pulses. Using a single pulse mode w
ith 10 mJ a micropuncture of the trabecular meshwork can be achieved w
ithout damaging the adjacent tissue. Using multiple pulses or higher e
nergy levels leads to damage of the posterior wall of Schlemm's canal
and to thermal side effects. Conclusions: Endoscope guided erbium-YAG
laser effects on trabecular tissue are comparable to those produced by
a 308 nm excimer laser. Therefore, a similar reduction in intraocular
pressure can be expected.