EFFECT OF GASTRIC-ACID SUPPRESSANTS ON HUMAN GASTRIC-MOTILITY

Background-The effect of histamine H-2 receptor antagonists on gastric emptying is controversial. Aims-To determine the effects of ranitidin e, famotidine, and omeprazole on gastric motility and emptying. Patien ts and methods-Fifteen normal subjects underwent simultaneous antroduo denal manometry, electrogastrography (EGG), and gastric emptying with dynamic antral scintigraphy (DAS). After 30 minutes of fasting manomet ry and EGG recording, subjects received either intravenous saline, ran itidine, or famotidine, followed by another 30 minutes recording and t hen three hours of post-prandial recording after ingestion of a radiol abelled meal. Images were obtained every 10-15 minutes for three hours to measure gastric emptying and assess antral contractility. Similar testing was performed after omeprazole 20 mg daily for one week. Resul ts-Fasting antral phase III migrating motor complexes (MMCs) were more common after ranitidine (9/15 subjects, 60%), famotidine (12/15, 80%) , and omeprazole (8/2, 67%) compared with placebo (4/14, 29%; p<0.05). Postprandially, ranitidine, famotidine, and omeprazole slowed gastric emptying, increased the amplitude of DAS contractions, increased the EGG power, and Increased the antral manometric motility index. Conclus ions-Suppression of gastric acid secretion with therapeutic doses of g astric acid suppressants is associated with delayed gastric emptying b ut increased antral motility.