KINETICS OF DEVELOPMENT OF HUMAN-MELANOMA XENOGRAFTS IN IMMUNOSUPPRESSED ANIMALS

Authors
OSTROVSKAYA LA ULYANOVA NM FOMINA MM RYKOVA VA KONRADOV AA BRIN EF GORBUNOVA NV GORBACHEVA LB KHALEEV DV
Citation
La. Ostrovskaya et al., KINETICS OF DEVELOPMENT OF HUMAN-MELANOMA XENOGRAFTS IN IMMUNOSUPPRESSED ANIMALS, Izvestia Akademii nauk SSSR. Seria biologiceskaa, (1), 1998, pp. 5-13
Citations number
21
Categorie Soggetti
Biology
Journal title
Izvestia Akademii nauk SSSR. Seria biologiceskaa → ACNP
ISSN journal
00023329
Issue
1
Year of publication
1998
Pages
5 - 13
Database
ISI
SICI code
0002-3329(1998):1<5:KODOHX>2.0.ZU;2-5
Abstract
An experimental model of development of the human tumor xenografts (me lanomas HCMB and Bro) in immunosuppressed phenotypically normal animal s (CBA/Ca mice) was developed. Optimal conditions were established for immunodeficiency induction in the animals. Kinetics of development of the xenografts in the immunosuppressed animals was studied. The level of 0(6)-alkyl-guanine-DNA-alkyltransferase, an enzyme responsible for repair of DNA damage in the tumor cells induced by chemotherapeutic a gents (nitroalkylutrea), was determined.