CERTAIN ASPECTS OF HEPARIN-SEROTONIN COMP LEX ACTION ON THE BLOOD ANDBLOOD-STREAM

High-molecular heparin-serotonin complex (3:1 weight ratio) was obtain ed in vitro. The complex, its components, and heparin-serotonin mixtur e were introduced intraperitoneally in rats, and the resulting effects were registered 10, 30, and 60 min later. The complex had anticoagula nt and lytic activities distinct from those of plasmin. According to d ecrease activity of factor XIII and decreased concentration of fibrino gen, the complex stimulated the anticoagulant system, In addition, the heparin-serotonin complex penetrated the hematoencephalic barrier and decreased the rate of brain bloodstream. The observed physiological p roperties of the heparin-serotonin complex were distinct from those of serotonin, heparin, and their mixture.