LOSS OF SEROTONIN-CONTAINING NEURONS IN THE RAPHE OF PATIENTS WITH MYOTONIC-DYSTROPHY - A QUANTITATIVE IMMUNOHISTOCHEMICAL STUDY AND RELATION TO HYPERSOMNIA

Authors
ONO S TAKAHASHI K JINNAI K KANDA F FUKUOKA Y KURISAKI H MITAKE S INAGAKI T YAMANO T NAGAO K
Citation
S. Ono et al., LOSS OF SEROTONIN-CONTAINING NEURONS IN THE RAPHE OF PATIENTS WITH MYOTONIC-DYSTROPHY - A QUANTITATIVE IMMUNOHISTOCHEMICAL STUDY AND RELATION TO HYPERSOMNIA, Neurology, 50(2), 1998, pp. 535-538
Citations number
10
Categorie Soggetti
Clinical Neurology
Journal title
Neurology → ACNP
ISSN journal
00283878
Volume
50
Issue
2
Year of publication
1998
Pages
535 - 538
Database
ISI
SICI code
0028-3878(1998)50:2<535:LOSNIT>2.0.ZU;2-8
Abstract
Hypersomnia occurs frequently in patients with myotonic dystrophy (MyD ). We performed a quantitative immunohistochemical study of serotonin (5-HT)-containing neurons linked to hypersomnia in the dorsal raphe nu cleus (DRN) and the superior central nucleus (SCN) in 8 patients with MyD, 5 of whom showed hypersomnia, and in 12 age-matched controls. The densities of 5-HT neurons in the DRN and the SCN were significantly l ower in MyD patients with hypersomnia than in MyD patients without hyp ersomnia and controls. These data suggest that the loss of 5-HT neuron s of the DRN and the SCN is associated with the presence of hypersomni a in MyD.