Growth failure is a major aspect of the developmental arrest in Rett s
yndrome. Small hands and feet have been reported anecdotally, but the
pattern of hand and foot growth has not been studied rigorously. The a
ims of this study were to characterize the hand and foot growth of 28
girls with Rett syndrome and to examine the relationship between their
hand or foot size and height, Median hand length deviated to the 5th
percentile at 11 years of age whereas median foot length and height de
viated below the 5th percentile at 5.5 years of age. After adjusting f
or height-age, a greater proportion of foot lengths than hand lengths
was less than the 50th percentile. In conclusion, the rate of hand and
foot growth of girls with Rett syndrome is slower than that of the no
rmal female. Moreover, the rate of deceleration of foot, but not hand,
growth relative to height growth is greater. Thus, many girls with Re
tt syndrome have ''small'' feet, but not hands, for their height.