MULTICENTRIC GIANT-CELL TUMOR WITH VIRAL-LIKE INCLUSIONS ASSOCIATED WITH PAGETS-DISEASE OF BONE - A CASE TREATED BY STEROID-THERAPY

Authors
DECHIARA A APICE G FAZIOLI F SILVESTRO P CARONE G MANCO A
Citation
A. Dechiara et al., MULTICENTRIC GIANT-CELL TUMOR WITH VIRAL-LIKE INCLUSIONS ASSOCIATED WITH PAGETS-DISEASE OF BONE - A CASE TREATED BY STEROID-THERAPY, Oncology Reports, 5(2), 1998, pp. 317-320
Citations number
25
Categorie Soggetti
Oncology
Journal title
Oncology Reports → ACNP
ISSN journal
1021335X
Volume
5
Issue
2
Year of publication
1998
Pages
317 - 320
Database
ISI
SICI code
1021-335X(1998)5:2<317:MGTWVI>2.0.ZU;2-1
Abstract
We report a case of giant cell tumor of bone (GCTB) associated with Pa ger's disease unsuccessfully treated with radiotherapy for some years but dramatically reduced in size with high dose of dexamethasone withi n few days. An ultrastructural study showed intranuclear virus-like in clusions in the multinucleated giant cells. The patient was then switc hed to prednisone plus diclofenac and he is still in almost complete r emission after two years. The patient was from Avellino area, a small town in Southern Italy.