A. Dechiara et al., MULTICENTRIC GIANT-CELL TUMOR WITH VIRAL-LIKE INCLUSIONS ASSOCIATED WITH PAGETS-DISEASE OF BONE - A CASE TREATED BY STEROID-THERAPY, Oncology Reports, 5(2), 1998, pp. 317-320
We report a case of giant cell tumor of bone (GCTB) associated with Pa
ger's disease unsuccessfully treated with radiotherapy for some years
but dramatically reduced in size with high dose of dexamethasone withi
n few days. An ultrastructural study showed intranuclear virus-like in
clusions in the multinucleated giant cells. The patient was then switc
hed to prednisone plus diclofenac and he is still in almost complete r
emission after two years. The patient was from Avellino area, a small
town in Southern Italy.