RELATIONSHIPS BETWEEN THE CHEMICAL-STRUCTURE OF ANTIMYCOBACTERIAL SUBSTANCES AND THEIR ACTIVITY AGAINST ATYPICAL STRAINS - PART 14 - L-6,8-DIHALOGENO-2H-1,3-BENZOXAZINE-2,4(3H)-DIONES

A set of eight derivatives of 6,8-dichloro-3-phenyl-2H-benzoxazine-2,4 (3H)-dione and nine derivatives of dibromo-3-phenyl-2H-1,3-benzoxazine -2,4(3H)-dione, substituted on the phenyl ring, was prepared by the re action of the corresponding salicylanilides with ethyl chloroformate. The compounds were evaluated in vitro for antimycobacterial activity a gainst Mycobacterium tuberculosis, Mycobacterium kansasii, and Mycobac terium avium. Their activity increases with increasing hydrophobicity and electron-withdrawing ability of the substituents on the phenyl rin g.