GASTROPROTECTIVE ACTIVITY OF THE STEM BARK OF AMPHIPTERYGIUM ADSTRINGENS IN RATS

Authors
NAVARRETE A MARTINEZURIBE LS REYES B
Citation
A. Navarrete et al., GASTROPROTECTIVE ACTIVITY OF THE STEM BARK OF AMPHIPTERYGIUM ADSTRINGENS IN RATS, PTR. Phytotherapy research, 12(1), 1998, pp. 1-4
Citations number
10
Categorie Soggetti
Chemistry Medicinal","Pharmacology & Pharmacy
Journal title
PTR. Phytotherapy research → ACNP
ISSN journal
0951418X
Volume
12
Issue
1
Year of publication
1998
Pages
1 - 4
Database
ISI
SICI code
0951-418X(1998)12:1<1:GAOTSB>2.0.ZU;2-7
Abstract
The methanol extract of the stem bark of Amphipterygium adstringens (J ulianiaceae) showed a dose-dependent inhibitory effect on ethanol-indu ced gastric ulcers in rats, Fractionation of this extract, guided by g astroprotective activity in rats, led to four active fractions rich in triterpenoid compounds, These fractions showed higher antiulcer activ ity than bismuth subsalicylate, used as a positive control, 3 alpha-Hy droxymasticadienonic acid was isolated from the active fractions, howe ver, this compound showed lower antiulcer activity than the positive c ontrol. (C) 1998 John Wiley & Sons, Ltd.