CONTRIBUTION OF THE ANTILIPID PEROXIDATIVE ACTION OF DAI-SAIKO-TO EXTRACT TO ITS PREVENTIVE EFFECT ON CARBON TETRACHLORIDE-INDUCED ACUTE LIVER-INJURY IN RATS

Authors
OHTA Y SASAKI E NISHIDA K KONGO M HAYASHI T NAGATA M ISHIGURO I
Citation
Y. Ohta et al., CONTRIBUTION OF THE ANTILIPID PEROXIDATIVE ACTION OF DAI-SAIKO-TO EXTRACT TO ITS PREVENTIVE EFFECT ON CARBON TETRACHLORIDE-INDUCED ACUTE LIVER-INJURY IN RATS, PTR. Phytotherapy research, 12(1), 1998, pp. 5-8
Citations number
11
Categorie Soggetti
Chemistry Medicinal","Pharmacology & Pharmacy
Journal title
PTR. Phytotherapy research → ACNP
ISSN journal
0951418X
Volume
12
Issue
1
Year of publication
1998
Pages
5 - 8
Database
ISI
SICI code
0951-418X(1998)12:1<5:COTAPA>2.0.ZU;2-N
Abstract
Post-oral administration of Dai-saiko-to extract (TJ-8), a traditional herbal medicine, ameliorated acute liver injury in rats intoxicated w ith carbon tetrachloride (CCl4). This TJ-8 administration inhibited an increase in lipid peroxide contents in the liver homogenate and micro somal fraction and a decrease in glucose-6-phosphatase activity in the liver microsomal fraction, an index of lipid peroxidation-mediated da mage in liver microsomes, during the progression and recovery of the l iver injury, These results indicate that the antilipid peroxidative ac tion of TJ-8 contributes to its preventive effect on CCl4-induced acut e liver injury in rats. (C) 1998 John Wiley & Sons, Ltd.