SYNTHESIS OF A BENZODIOXINIC ANALOG OF ELLIPTICINE AND EVALUATION OF ITS ANTITUMOR-ACTIVITY

Authors
RUIZ N BOUYSSOU P RAPP M MAURIZIS JC MADELMONT JC COUDERT G
Citation
N. Ruiz et al., SYNTHESIS OF A BENZODIOXINIC ANALOG OF ELLIPTICINE AND EVALUATION OF ITS ANTITUMOR-ACTIVITY, Heterocyclic communications, 3(6), 1997, pp. 509-514
Citations number
13
Journal title
Heterocyclic communications → ACNP
ISSN journal
07930283
Volume
3
Issue
6
Year of publication
1997
Pages
509 - 514
Database
ISI
SICI code
0793-0283(1997)3:6<509:SOABAO>2.0.ZU;2-9
Abstract
A benzodioxinic analogue of Ellipticine was synthesized, using two str ategies both involving a Diels Alder cycloaddition of furobenzodioxin. Antitumor activity was evaluated in vitro and in vivo on B 16 melanom a and P 388 Leukemia.