SPLICING - HACKING INTO THE UNFOLDED-PROTEIN RESPONSE

Authors
SHAMU CE
Citation
Ce. Shamu, SPLICING - HACKING INTO THE UNFOLDED-PROTEIN RESPONSE, Current biology, 8(4), 1998, pp. 121-123
Citations number
18
Categorie Soggetti
Biology,Biology
Journal title
Current biology → ACNP
ISSN journal
09609822
Volume
8
Issue
4
Year of publication
1998
Pages
121 - 123
Database
ISI
SICI code
0960-9822(1998)8:4<121:S-HITU>2.0.ZU;2-D
Abstract
Unfolded proteins in the endoplasmic reticulum of Saccharomyces cerevi siae trigger a specialized RNA splicing event that allows the subseque nt translation of the Hac1p transcription factor. This splicing can be reconstituted with Ire1p, a transmembrane kinase that has a site-spec ific RNase activity, and tRNA ligase. (C) Current Biology Ltd.