STOPPED-FLOW SPECTROPHOTOMETRIC DETERMINATION OF DOPAMINE AND METHYLDOPA WITH SODIUM-HYDROXIDE

Authors
BERZAS JJ LEMUS JM BUITRAGO P
Citation
Jj. Berzas et al., STOPPED-FLOW SPECTROPHOTOMETRIC DETERMINATION OF DOPAMINE AND METHYLDOPA WITH SODIUM-HYDROXIDE, Analytical letters, 30(6), 1997, pp. 1109-1120
Citations number
18
Categorie Soggetti
Chemistry Analytical
Journal title
Analytical letters → ACNP
ISSN journal
00032719
Volume
30
Issue
6
Year of publication
1997
Pages
1109 - 1120
Database
ISI
SICI code
0003-2719(1997)30:6<1109:SSDODA>2.0.ZU;2-M
Abstract
A stopped flow method for the determination of dopamine and methyldopa is proposed. The method is based on the aerial oxidation of these cat echolamines in strong alkali medium. The method was optimized using a spectrophotometer (lambda = 360 nm) as detector. Calibration graphs we re linear up to 2 x 10(-4) mol/L for dopamine and 3.0 x 10(-4) mol/L f or methyldopa with quantification limits of 3.5 x 10(-6) mol/L and 4.3 x 10(-7) mol/L for dopamine and methyldopa, respectively. The method was successfully applied to the determination of catecholamines in pha rmaceutical formulations.