HOMOLOGATED AZA ANALOGS OF ARABINOSE AS ANTIMYCOBACTERIAL AGENTS

Authors
MADDRY JA BANSAL N BERMUDEZ LE COMBER RN ORME IM SULING WJ WILSON LN REYNOLDS RC
Citation
Ja. Maddry et al., HOMOLOGATED AZA ANALOGS OF ARABINOSE AS ANTIMYCOBACTERIAL AGENTS, Bioorganic & medicinal chemistry letters, 8(3), 1998, pp. 237-242
Citations number
30
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
3
Year of publication
1998
Pages
237 - 242
Database
ISI
SICI code
0960-894X(1998)8:3<237:HAAOAA>2.0.ZU;2-R
Abstract
A series of hydrolytically-stable aza analogs of arabinofuranose was p repared and evaluated against Mycobacterium tuberculosis and M avium. The compounds were designed to mimic the putative arabinose donor invo lved in biogenesis of the essential cell wall polysaccharide, arabinog alactan. Though most compounds displayed little activity in cell cultu re, one compound showed significant activity in infected macrophage mo dels. (C) 1998 Elsevier Science Ltd. All rights reserved.