A PACLITAXEL ANALOG WITH A 2(3-]20)ABEOTAXANE SKELETON - SYNTHESIS AND BIOLOGICAL EVALUATION

Authors
SOTO J MASCARENAS JL CASTEDO L
Citation
J. Soto et al., A PACLITAXEL ANALOG WITH A 2(3-]20)ABEOTAXANE SKELETON - SYNTHESIS AND BIOLOGICAL EVALUATION, Bioorganic & medicinal chemistry letters, 8(3), 1998, pp. 273-276
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
3
Year of publication
1998
Pages
273 - 276
Database
ISI
SICI code
0960-894X(1998)8:3<273:APAWA2>2.0.ZU;2-I
Abstract
A paclitaxel analogue having an unusual tricyclic [9.3.1.1] hexadecane skeleton was synthesized from deaminoacyltaxine A, a 2(3-->20) abeota xane isolated in considerable amounts from the leaves of Tarus baccata L. In preliminary studies, this compound showed a much lower cytotoxi city than paclitaxel. (C) 1998 Elsevier Science Ltd. All rights reserv ed.