SYNTHESES OF NEW MODIFIED PHE-PRO PEPTIDES - USE OF PROLINE REPLACEMENTS IN POTENTIAL HIV INHIBITORS

Authors
BOUYGUES M MEDOU M QUELEVER G CHERMANN JC CAMPLO M KRAUS JL
Citation
M. Bouygues et al., SYNTHESES OF NEW MODIFIED PHE-PRO PEPTIDES - USE OF PROLINE REPLACEMENTS IN POTENTIAL HIV INHIBITORS, Bioorganic & medicinal chemistry letters, 8(3), 1998, pp. 277-280
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
3
Year of publication
1998
Pages
277 - 280
Database
ISI
SICI code
0960-894X(1998)8:3<277:SONMPP>2.0.ZU;2-6
Abstract
The syntheses consisting of replacement of proline amino acid by a 3-p yrrolidinone ring in Phe-Pro analogues are described. Preliminary anti -HIV studies demonstrated the potential activity of this new class of compounds. (C) 1998 Elsevier Science Ltd. All rights reserved.