RAPID HYDROLYSIS OF AMIDES UNDER PHYSIOLOGICAL CONDITIONS - INFLUENCEOF THE MICROENVIRONMENT ON THE STABILITY OF AMIDE BOND

Authors
GLUSENKAMP KH MENGEDE C DROSDZIOK W JAHDE E RAJEWSKY MF
Citation
Kh. Glusenkamp et al., RAPID HYDROLYSIS OF AMIDES UNDER PHYSIOLOGICAL CONDITIONS - INFLUENCEOF THE MICROENVIRONMENT ON THE STABILITY OF AMIDE BOND, Bioorganic & medicinal chemistry letters, 8(3), 1998, pp. 285-288
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
3
Year of publication
1998
Pages
285 - 288
Database
ISI
SICI code
0960-894X(1998)8:3<285:RHOAUP>2.0.ZU;2-K
Abstract
A new class of bicyclic carboxyamides 1a-9a differing with respect to substitution patterns and exo-endo geometry has been synthesized. Thes e amides are characterized by a structure-dependent unusual rapid hydr olysis rate at physiological conditions. The corresponding bicyclic an hydrides might be used as tools for masking and modifiying therapeutic agents containing amine functionalities. (C) 1998 Elsevier Science Lt d. All rights reserved.