INHIBITORS OF ACYL-COA-CHOLESTEROL O-ACYLTRANSFERASE (ACAT) AS HYPOCHOLESTEROLEMIC AGENTS - SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF NOVEL SERIES OF SULFONAMIDES, ACYLPHOSPHONAMIDES AND ACYLPHOSPHORAMIDATES

Authors
LEE HT ROARK WH PICARD JA SLISKOVIC DR ROTH BD STANFIELD RL HAMELEHLE KL BOUSLEY RF KRAUSE BR
Citation
Ht. Lee et al., INHIBITORS OF ACYL-COA-CHOLESTEROL O-ACYLTRANSFERASE (ACAT) AS HYPOCHOLESTEROLEMIC AGENTS - SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF NOVEL SERIES OF SULFONAMIDES, ACYLPHOSPHONAMIDES AND ACYLPHOSPHORAMIDATES, Bioorganic & medicinal chemistry letters, 8(3), 1998, pp. 289-294
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
3
Year of publication
1998
Pages
289 - 294
Database
ISI
SICI code
0960-894X(1998)8:3<289:IOAO(A>2.0.ZU;2-F
Abstract
Sulfoacetic acid, phosphoramidate, and phosphonamide analogs of the AC AT inhibitors, CI-999 and CI-1011 were synthesized. The structure-acti vity relationships of these compounds as ACAT inhibitors are described . (C) 1998 Elsevier Science Ltd. All rights reserved.