NEW-GENERATION DOPAMINERGIC AGENTS - 2 - DISCOVERY OF 3-OH-PHENOXYETHNAMINE AND 3-OH-N-1-PHENYLPIPERAZINE DOPAMINERGIC TEMPLATES

Authors
MEWSHAW RE HUSBANDS M GILDERSLEEVE ES WEBB MB SHI XJ MAZANDARANI H COCKETT MI OCHALSKI R BRENNAN JA ABOUGHARBIA M MARQUIS K MCGAUGHEY GB COUPET J ANDREE TH
Citation
Re. Mewshaw et al., NEW-GENERATION DOPAMINERGIC AGENTS - 2 - DISCOVERY OF 3-OH-PHENOXYETHNAMINE AND 3-OH-N-1-PHENYLPIPERAZINE DOPAMINERGIC TEMPLATES, Bioorganic & medicinal chemistry letters, 8(3), 1998, pp. 295-300
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
3
Year of publication
1998
Pages
295 - 300
Database
ISI
SICI code
0960-894X(1998)8:3<295:NDA-2->2.0.ZU;2-1
Abstract
Described in this report is a systematic study which led to the identi fication of two new dopamine D-2 partial agonists (5 and 17). Phenols 5 and 17 represent prototypes of two new classes of D-2 partial agonis ts as well as templates for the future design of novel dopaminergic ag ents. (C) 1998 Elsevier Science Ltd. All rights reserved.