STRUCTURE-ACTIVITY-RELATIONSHIPS (SAR) OF SOME TETRACYCLIC HETEROCYCLES RELATED TO THE IMMUNOSUPPRESSIVE AGENT BREQUINAR SODIUM

Authors
PITTS WJ JETTER JW PINTO DJ ORWAT MJ BATT DG SHERK SR PETRAITIS JJ JACOBSON IC COPELAND RA DOWLING RL JAFFEE BD GARDNER TL JONES EA MAGOLDA RL
Citation
Wj. Pitts et al., STRUCTURE-ACTIVITY-RELATIONSHIPS (SAR) OF SOME TETRACYCLIC HETEROCYCLES RELATED TO THE IMMUNOSUPPRESSIVE AGENT BREQUINAR SODIUM, Bioorganic & medicinal chemistry letters, 8(3), 1998, pp. 307-312
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
3
Year of publication
1998
Pages
307 - 312
Database
ISI
SICI code
0960-894X(1998)8:3<307:S(OSTH>2.0.ZU;2-S
Abstract
The structure-activity relationships of some tetracyclic heterocycles related to Brequinar were explored. Activities as inhibitors of dihydr oorotate dehydrogenase and the mixed lymphocyte reaction are related t o ring system, heteroatom placement, and pendant ring substitution. (C ) 1998 The DuPont Merck Pharmaceutical Company. Published by Elsevier Science Ltd.