LACK OF ASSOCIATION BETWEEN SCHIZOPHRENIA AND HLA DQB1 ALLELES IN A SWEDISH SAMPLE

Three studies have reported a negative genetic association between sch izophrenia and HLA DQB10602, an allele of the human leucocyte antigen (HLA) DQB106 gene, In a sample of ethnic all homogeneous Caucasians living in Sweden, the frequency of HLA DQB1 alleles in patients with s chizophrenia (n = 124) was compared with that in a control group (n = 85). No significant differences were found. Together with previous inv estigations, the present study indicates that the reported genetic ass ociation of DQB10602 with schizophrenia may be limited to non-Caucasi ans. (C) 1998 Elsevier Science B.V.