PROTEIN-BINDING OF ANESTHETICS AND ADJUVA NT DRUGS

Authors
WIESNER G GRUBER M HOERAUF K TAEGER K
Citation
G. Wiesner et al., PROTEIN-BINDING OF ANESTHETICS AND ADJUVA NT DRUGS, Anasthesiologie und Intensivmedizin, 39(1), 1998, pp. 19-27
Citations number
102
Categorie Soggetti
Anesthesiology,"Emergency Medicine & Critical Care
Journal title
Anasthesiologie und Intensivmedizin → ACNP
ISSN journal
01705334
Volume
39
Issue
1
Year of publication
1998
Pages
19 - 27
Database
ISI
SICI code
0170-5334(1998)39:1<19:POAAAN>2.0.ZU;2-0
Abstract
Many anaesthetics are extensively bound to plasma proteins. This revie w article deals with the basic principles and the perioperative variab ility of protein binding. Furthermore the effects of perioperative alt erations of protein binding on the pharmacokinetics and pharmacodynami cs are elucidated. Many studies confirm the influence of protein bindi ng on the uptake, (re)distribution, biotransformation and elimination of anaesthetics whereas the influence on drug effect is difficult to a ssess.