PANTOPRAZOLE-BASED 10-DAY TRIPLE THERAPY IS EFFECTIVE IN HELICOBACTER-PYLORI ERADICATION

Aim: To investigate the efficacy of a short course of pantoprazole-bas ed triple therapy in Helicobater pylori eradication in a single-centre pilot study. Methods: Patients with active or healed duodenal ulcer o r with gastric erosions or gastritis, all of whom were H. pylori-posit ive, received 10 days of twice-daily open treatment with pantoprazole 40 mg, plus clarithromycin 250 mg and tinidazole 500 mg. H. pylori was assessed at entry and 28-35 days after the end of treatment by rapid urease test (at entry only), culture and antimicrobial sensitivity, hi stology and C-13 urea breath test, The criterion for eradication was a negative result in all three tests. Results: Seventy patients were tr eated, of whom four were excluded from analysis due to major deviation s from the study protocol, Eradication of H. pylori was achieved in 57 /66 patients (per protocol analysis 86% (95% CI: 78-95%)) and was high er in patients with organisms sensitive to nitroimidazole before treat ment (sensitive: 47/53 (89%), insensitive: 10/13 (77%)). There was mar ked reduction in acute throughout the stomach while chronic gastritis decreased only in the corpus, Healing was achieved in all 24 patients with active duodenal ulcer, Treatment was complied with; only one pati ent missed one of the 20 doses, Adverse events were of mild or moderat e intensity and did not require withdrawal from treatment. Conclusion: A short course of pantoprazole-based triple therapy is well tolerated and effective in eradicating H. pylori.