INTERFERONS AND OTHER CYTOKINES IN HEAD AND NECK-CANCER

The use of cytokines in head and neck cancer is increasingly under inv estigation. Clinical trials have tested the interferons, interleukin-2 and other cytokines as single agents and in various combinations. The addition of interferon to the cisplatin and 5-fluorouracil (5-FU) reg imens (with and without leucovorin) has been explored. A randomized in ternational trial comparing cisplatin and 5-FU with cisplatin, 5-FU an d interferon-alpha 2b is in progress.