SYNTHESIS OF BIOREDUCTIVELY ACTIVATED ALKYLATING HOECHST-33258 ANALOGS

Authors
ZHAO RL LOWN JW
Citation
Rl. Zhao et Jw. Lown, SYNTHESIS OF BIOREDUCTIVELY ACTIVATED ALKYLATING HOECHST-33258 ANALOGS, Heterocyclic communications, 4(1), 1998, pp. 11-19
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocyclic communications → ACNP
ISSN journal
07930283
Volume
4
Issue
1
Year of publication
1998
Pages
11 - 19
Database
ISI
SICI code
0793-0283(1998)4:1<11:SOBAAH>2.0.ZU;2-7
Abstract
A series of DNA-interactive bis-benzimidazole analogues of Hoechst 332 58 was prepared to explore the potential for anticancer activity media ted for certain of the drugs via bioreductive activation by endogenous NADH or NADPH.