SYNTHESIS AND ACTIVITIES OF 5-SUBSTITUTED-2-(P-SUBSTITUTED PHENYL)-1-DIALKYLAMINOMETHYL BENZIMIDAZOLE DERIVATIVES

Citation
S. Uzunoglu et al., SYNTHESIS AND ACTIVITIES OF 5-SUBSTITUTED-2-(P-SUBSTITUTED PHENYL)-1-DIALKYLAMINOMETHYL BENZIMIDAZOLE DERIVATIVES, Il Farmaco, 52(10), 1997, pp. 619-623
Citations number
32
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
ISSN journal
0014827X
Volume
52
Issue
10
Year of publication
1997
Pages
619 - 623
Database
ISI
SICI code
0014-827X(1997)52:10<619:SAAO5P>2.0.ZU;2-A
Abstract
Nine 1,2,5-trisubstituted benzimidazole derivatives were prepared and their structure have been elucidated by IR, NMR spectral data and elem ental analyses. Analgesic activity of the compounds prepared was inves tigated in mice by modified KOSTER test. Anti-inflammatory activity of these compounds was investigated by a carregeenan-induced hind paw ed ema model in mice. Their antibacterial activities were examined againt s S, aureus, E. faecalis, E. coli, P. aeruginosa, and antifungal activ ity against three kinds of yeast-like fungi (C. albicans, C. parapsilo sis, C. stellatoidea).