SYNTHESIS AND ACTIVITIES OF 5-SUBSTITUTED-2-(P-SUBSTITUTED PHENYL)-1-DIALKYLAMINOMETHYL BENZIMIDAZOLE DERIVATIVES

Nine 1,2,5-trisubstituted benzimidazole derivatives were prepared and their structure have been elucidated by IR, NMR spectral data and elem ental analyses. Analgesic activity of the compounds prepared was inves tigated in mice by modified KOSTER test. Anti-inflammatory activity of these compounds was investigated by a carregeenan-induced hind paw ed ema model in mice. Their antibacterial activities were examined againt s S, aureus, E. faecalis, E. coli, P. aeruginosa, and antifungal activ ity against three kinds of yeast-like fungi (C. albicans, C. parapsilo sis, C. stellatoidea).