DISSOLUTION RATE OF FUROSEMIDE FROM POLYETHYLENE-GLYCOL SOLID DISPERSIONS

In this study, by preparing the solid dispersions of furosemide, a sub stance that is poor-soluble in water, with polyethylene glycol 6000, 1 0000 and 20000, the enhancement of the dissolution rate of furosemide has been aimed. Solid dispersions were prepared by the fusion method i n proportions of 1:4, 1:6 and 1:10 (active material/polymer). The form ation of solid dispersion was tested by the techniques of X-ray diffra ction, differential calorimetry (DSC) and infrared spectroscopy (IR). The release rate of active material from the solid dispersions prepare d was examined by using the flow through cell method. Also, the effect of particle size of the complexes obtained, on the dissolution rate a nd the stabilities of these complexes were studied. It was determined that the dissolution rate of furosemide was markedly increased along w ith the formation of the complex and that a better dissolution profile was obtained even in the physical mixtures prepared for the purposes of comparison. It was found that the molecular weights of different ki nds of polyethylene glycols and the various proportions of active mate rial/polymer complexes as well as the particle sizes of the solid disp ersions were not efficient in the release rate of active material. It was concluded that the increase of the dissolution rate was being a re sult of both wettability and solubility enhancing effects of polyethyl ene glycols.