QUINOXALINE CHEMISTRY - PART 8 - 2-[ANILINO]-3-[CARBOXY]-6(7)-SUBSTITUTED QUINOXALINES AS NON CLASSICAL ANTIFOLATE AGENTS - SYNTHESIS AND EVALUATION OF IN-VITRO ANTICANCER, ANTI-HIV AND ANTIFUNGAL ACTIVITY

Authors
LORIGA M MORO P SANNA P PAGLIETTI G ZANETTI S
Citation
M. Loriga et al., QUINOXALINE CHEMISTRY - PART 8 - 2-[ANILINO]-3-[CARBOXY]-6(7)-SUBSTITUTED QUINOXALINES AS NON CLASSICAL ANTIFOLATE AGENTS - SYNTHESIS AND EVALUATION OF IN-VITRO ANTICANCER, ANTI-HIV AND ANTIFUNGAL ACTIVITY, Il Farmaco, 52(8-9), 1997, pp. 531-537
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
52
Issue
8-9
Year of publication
1997
Pages
531 - 537
Database
ISI
SICI code
0014-827X(1997)52:8-9<531:QC-P8->2.0.ZU;2-N
Abstract
Thirty quinoxalines bearing a substituted anilino group on position 2, a carboethoxy or carboxy group on position 3 and a trifluoromethyl gr oup on position 6 or 7 of the heterocycle were prepared in order to ev aluate in vitro anticancer activity. Preliminary screening performed a t NCI showed that most derivatives exhibited a moderate to strong grow th inhibition activity on various tumor panel cell lines between 10(-5 ) and 10(-4) molar concentrations. Interesting selectivities were also recorded between 10(-8) and 10(-6) M for a few compounds. One single compound exhibited good activity against Candida albicans.