SYNTHESIS AND ANTINEOPLASTIC ACTIVITY OF NEW 4-DIAZOPYRAZOLE DERIVATIVES

Authors
DAIDONE G MAGGIO B RAFFA D SCHILLACI D PLESCIA S
Citation
G. Daidone et al., SYNTHESIS AND ANTINEOPLASTIC ACTIVITY OF NEW 4-DIAZOPYRAZOLE DERIVATIVES, Il Farmaco, 52(8-9), 1997, pp. 557-559
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
52
Issue
8-9
Year of publication
1997
Pages
557 - 559
Database
ISI
SICI code
0014-827X(1997)52:8-9<557:SAAAON>2.0.ZU;2-Z
Abstract
Several new 4-diazopyrazole derivatives were synthesized by reaction o f R-substituted)phenyl-3-methyl-5-benzamidopyrazoles with a sevenfold excess of nitrous acid in acetic media. The compounds were tested at 2 0 mu M concentration for their antineoplastic activity in vitro agains t Raji (human Burkitt lymphoma), K562 (human chronic myelogenous leuke mia) and U937 (human histiocytic limphoma) cell lines. They showed a p ercent of growth inhibition in the range 23.4-100%.