CARDIOVASCULAR RISK-FACTORS IN PEOPLE WITH DIFFERENT GENOTYPES IN THEINSERTION DELETION (I/D) POLYMORPHISM AT THE LOCUS FOR ANGIOTENSIN-I-CONVERTING-ENZYME (ACE)/
Ke. Berge et K. Berg, CARDIOVASCULAR RISK-FACTORS IN PEOPLE WITH DIFFERENT GENOTYPES IN THEINSERTION DELETION (I/D) POLYMORPHISM AT THE LOCUS FOR ANGIOTENSIN-I-CONVERTING-ENZYME (ACE)/, Clinical genetics, 52(6), 1997, pp. 422-426
The deletion (D) allele of an insertion/deletion (I/D) polymorphism at
the locus for angiotensin I-converting enzyme (ACE) has been reported
to be an independent risk factor for myocardial infarction (MI), part
icularly in people lacking traditional risk factors. Furthermore, a bo
rderline association between Lp(a) lipoprotein level and the I/D polym
orphism at the ACE locus was reported in one study. We have searched f
or possible ''level gene'' or ''variability gene'' effects of ACE gene
s on Lp(a) lipoprotein, total cholesterol(TC), high density lipoprotei
n (HDL) cholesterol (HDLC), low density lipoprotein (LDL) cholesterol(
LDLC), triglycerides (TG), apolipoprotein B (apoB), apolipoprotein A-I
(apoA-I), and body mass index (BMI). None of these variables differed
significantly between genotypes in the I/D polymorphism in any of thr
ee population samples. A single population sample created by combining
the three series, exhibited an insignificant trend towards individual
s carrying the D-allele having a higher level of Lp(a) lipoprotein tha
n those lacking it, and DD homozygotes had a significantly higher Lp(a
) lipoprotein level than the combined group of ID/II individuals (p =
0.03). These results may indicate that the D-allele of the I/D polymor
phism at the ACE locus could influence the level of Lp(a) lipoprotein.