DYNAMIC KINETIC RESOLUTION

The equilibration of a mixture of enantiomers or diastereoisomers prio r to or during kinetic resolution permits the isolation of a single is omer of one product in >50% yield. Examples of such processes involvin g both enantioselective and diastereoselective reactions are discussed . In some cases highly efficient processes are available, yielding, fo r example, cyanohydrin acetates and alpha-substituted carboxylic acid derivatives in high yield and with high e.e. and d.e. respectively.