CLINICAL-EVALUATION OF AK-100 ULTRA FOR PREDILUTION HF WITH ONLINE PREPARED BICARBONATE SUBSTITUTION FLUID - COMPARISON WITH HD AND ACETATEPOSTDILUTION HF

Convective transport across dialysis membranes has been known for a lo ng time to be a good alternative to diffusion. Predilution hemofiltrat ion (HF) offers a better clearance of small molecules and overcomes th e blood viscosity problems related to conventional postdilution HF tre atment Three patients have performed a total of 293 predilution HF tre atment with AK 100 ULTRA. The bicarbonate substitution fluid has been prepared on-line by the machine. The treatments have been well tolerat ed and no adverse patients reactions related to the qualify of the sub stitution fluid or the predilution HF treatment have been observed. Th ere is a drop in creatinine for all patients indicating an improved cr eatinine clearance. Bicarbonate predilution HF has been shown to be a safe and efficient treatment modality, it offers the possibility to im prove the cardiovascular stability of patients having problems with ot her treatment modalities an it offers an improved intertreatment well- being for the patients.