THE USE OF WOBENZYM(R) TO FACILITATE INTERFERON SYNTHESIS IN THE TREATMENT OF CHRONIC UROGENITAL CHLAMYDIOSIS

Chlamydial infections are recognized as a major cause oi infertility i n couples and different types of pathology of male and female reproduc tive functions. Female endocervical smears and male urethral swabs wer e examined by polymerase chain reaction (PCR) in 3,200 patients. Optim al schedule of treatment of chronic urogenital chlamydiosis using prot eolytic enzymes (peroral tablet oi Wobenzym(R), Mucos Pharma, Geretsri ed, Germany) were proposed by us. in order to realize the mechanism of the therapeutic effect of proteinases we investigated the changes in the interferon system of patients. We found significant decrease oi IF N alpha-gamma production and increase oi serum IFN. Application of Wob enzym(R) led to normalization of leukocyte capability to synthesize IF N in response to ail inductors. Standard antibiotic therapy led to chl amydia elimination in 61% women and 45% men; combination of antibiotic therapy with Wobenzym(R) resulted in 92% cases with women and 89.5% w ith men, respectively The blockade of interferon synthesis by leukocyt es seems to be the cause of long-term prolongation of chlamydial infec tion inducing inflammation in the genital tract. Proteinases coming in to the blood relieve the blockade of non-specific antibacterial defens e. Thus, proteolytic enzymes were shown as a highly efficient strength ening factor for antibiotic therapy of urogenital chlamydiosis.