PLEURAL TUBERCULOSIS IN HARARE, ZIMBABWE - THE RELATIONSHIP BETWEEN HUMAN-IMMUNODEFICIENCY-VIRUS, CD4 LYMPHOCYTE COUNT, GRANULOMA-FORMATIONAND DISSEMINATED DISEASE

OBJECTIVE To elucidate the relationship between HIV, CD4(+) count and pleural TB. METHOD In a prospective study, 94 patients presenting at t wo large Harare hospitals with clinically suspected pleural TB were en rolled over a 10-month period. All underwent standardized evaluation, closed pleural aspiration and biopsy. Patients receiving directly obse rved anti-TB therapy were followed-up. RESULTS Pleural TB was diagnose d in 90 individuals (median age 33 years; range 18-65; 64 males); the seroprevalence of HIV was 85%. HIV-positive patients were older than H IV-negative individuals (median age 33 vs 23 years, P = 0.013) and had a significantly lower median CD4(+) count (191 vs 1106 x 10(6)/1 resp ectively, P = 0.004). A CD4(+) count of <200 x 10(6)/1 was associated with a length of illness >30 days (65% vs 37%; P = 0.05), a positive p leural fluid smear (37% vs 0%; P = 0.0006) and a positive pleural biop sy Ziehl-Neelsen stain (35% vs 7%; P = 0.021). However, a relationship between CD4(+) count and either pleural granuloma formation or radiol ogical evidence of disseminated disease was not observed. CONCLUSION I n sub-Saharan Africa, TB pleural effusions have become associated with older age, a chronic onset, and an increased mycobacterial load. Thes e data emphasize the complex relationship between pleural TB, HIV infe ction and a low CD4(+) count.