LIPASE-CATALYZED KINETIC RESOLUTION OF PHARMACEUTICALLY USEFUL CHLOROALCOHOLS IN HEPTANE

Authors
RAJU SB CHIOU TW TAI DF
Citation
Sb. Raju et al., LIPASE-CATALYZED KINETIC RESOLUTION OF PHARMACEUTICALLY USEFUL CHLOROALCOHOLS IN HEPTANE, Tetrahedron : asymmetry, 6(7), 1995, pp. 1519-1520
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
6
Issue
7
Year of publication
1995
Pages
1519 - 1520
Database
ISI
SICI code
0957-4166(1995)6:7<1519:LKROPU>2.0.ZU;2-9
Abstract
Pharmaceutically useful chloro alcohols, 3-chloro-1-phenyl-1-propanol( 1), 1-chloro-3-(1-naphthyloxy)-2-propanol (2) and 4-chloro-1-(4-tert-b utylphenyl)-1-butanol (3), are prepared in enantiomerically pure form by an efficient lipase PS catalyzed transesterification in heptane. Th e effect of organic solvent nature on enzyme activity was also studied .