INHIBITION OF SPERM GLUTATHIONE-S-TRANSFERASE LEADS TO FUNCTIONAL IMPAIRMENT DUE TO MEMBRANE DAMAGE

Citation
B. Gopalakrishnan et C. Shaha, INHIBITION OF SPERM GLUTATHIONE-S-TRANSFERASE LEADS TO FUNCTIONAL IMPAIRMENT DUE TO MEMBRANE DAMAGE, FEBS letters, 422(3), 1998, pp. 296-300
Citations number
23
Categorie Soggetti
Biology,"Cell Biology",Biophysics
Journal title
ISSN journal
00145793
Volume
422
Issue
3
Year of publication
1998
Pages
296 - 300
Database
ISI
SICI code
0014-5793(1998)422:3<296:IOSGLT>2.0.ZU;2-F
Abstract
The role of glutathione S-transferase (GST) in the defense mechanisms of sperm is not known. We report here interference with normal motilit y, acrosome reaction and fertilizing ability of the goat sperm as a co nsequence of inhibition of GST activity. That these functional impairm ents mere due to membrane changes was evident from the alteration in t he lipid peroxidation status of these cells after GST inhibitor treatm ent, Increased reactive oxygen species production by the cell which oc curred when CST activity was suppressed ma be the mediator for membran e damage, The data argue for a role of GST in maintaining sperm membra ne status. (C) 1998 Federation of European Biochemical Societies.