Picture archiving and communication systems (PACS) is a system integra
tion of multimodality images and health information systems designed f
or improving the operation of a radiology department. As it evolves, P
ACS becomes a hospital image document management system with a volumin
ous image and related data file repository. A medical image informatic
s infrastructure can be designed to take advantage of existing data, p
roviding PACS with add-on value for health care service, research, and
education. A medical image informatics infrastructure (MIII) consists
of the following components: medical images and associated data (incl
uding PACS database), image processing, data/knowledge base management
, visualization, graphic user interface, communication networking, and
application oriented software. This paper describes these components
and their logical connection, and illustrates some applications based
on the concept of the MIII.