SYNTHESIS OF ENANTIOMERICALLY PURE (R)-3-METHYL-2-CYCLOPENTEN-1-OL AND (S)-3-METHYL-2-CYCLOPENTEN-1-OL

Authors
ZHOU XM DECLERCQ PJ GAWRONSKI J
Citation
Xm. Zhou et al., SYNTHESIS OF ENANTIOMERICALLY PURE (R)-3-METHYL-2-CYCLOPENTEN-1-OL AND (S)-3-METHYL-2-CYCLOPENTEN-1-OL, Tetrahedron : asymmetry, 6(7), 1995, pp. 1551-1552
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
6
Issue
7
Year of publication
1995
Pages
1551 - 1552
Database
ISI
SICI code
0957-4166(1995)6:7<1551:SOEP(A>2.0.ZU;2-8
Abstract
(R)- and (S)-3-methyl-2-cyclopenten-1-ol are prepared from 3-methyl-2- cyclopentenone with high enantiomeric purity (>95 %) through a 4-step sequence involving the enantioselective enzymatic esterification of 2- bromo-3-methyl-2-cyclopenten-1-ol with lipase PS and vinyl acetate.