The stability to heat and cooking in ivermectin was investigated. The
drug was insufficiently soluble in water to allow the effect of heatin
g in simple aqueous solutions to be studied. The effect of a range of
cooking processes was investigated on pig muscle and liver, cattle mus
cle and liver and salmon muscle. The drug was found to be stable to th
e effect of cooking. Some leaching of ivermectin with juices as they e
xuded from the foods as they were cooked was observed; in one case thi
s amounted to about 50% of the total residue.