CHANGING PHENOTYPE IN FLOATING-HARBOR SYNDROME

We report on a girl with Floating-Harbor syndrome, trigonocephaly due to metopic suture synostosis, preauricular pit, hypoplastic thumb, sub luxated radial head, and Sprengel deformity. A review suggests that tr igonocephaly may be an important craniofacial manifestation in this sy ndrome that is recognizable in infancy. With time, this finding appear s to become less noticeable, and the face develops a triangular shape, accentuated by a broad and bulbous nose. (C) 1998 Wiley-Liss, Inc.