BIOCATALYTIC APPROACH TO ENANTIOMERICALLY PURE BETA-AMINO ACIDS

Authors
SOLOSHONOK VA FOKINA NA RYBAKOVA AV SHISHKINA IP GALUSHKO SV SOROCHINSKY AE KUKHAR VP SAVCHENKO MV SVEDAS VK
Citation
Va. Soloshonok et al., BIOCATALYTIC APPROACH TO ENANTIOMERICALLY PURE BETA-AMINO ACIDS, Tetrahedron : asymmetry, 6(7), 1995, pp. 1601-1610
Citations number
133
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
6
Issue
7
Year of publication
1995
Pages
1601 - 1610
Database
ISI
SICI code
0957-4166(1995)6:7<1601:BATEPB>2.0.ZU;2-X
Abstract
beta-Aryl-beta-amino acids were prepared in good chemical yield and hi gh enantiomeric purity (> 95% eel via penicillin acylase-catalyzed hyd rolysis of the corresponding N-phenylacetyl derivatives. The (R)-enant iomers were the fast-reacting isomers in all cases studied. The biocat alytic procedure described employs very simple set or reactions using inexpensive commercially available chemicals and enzyme, and could be easily scaled up.